Perioperative medicine & outcomes
Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1‐Year Follow‐Up of a Randomized Controlled Trial
Authors' conclusion
Differences in all-cause mortality, hospital admission, or MI were not statistically significant at 1-year follow-up for either oxygen fractions or antioxidant administration in patients undergoing major noncardiac surgery.
Study context
- Population
- Patients with cardiovascular risk factors scheduled for noncardiac surgery594 completed follow-up
- Participants
- 600 patients
- Comparison
- Fraction (FiO2) 0.80 vs 0.30; antioxidants vs placebo
- FiO2 of 0.80n = 298
- FiO2 of 0.30n = 296reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Methodological details2 × 2 factorial, preplanned 1-year follow-up, placebo-controlled
- 2 × 2 factorial
- Preplanned 1-year follow-up
- Placebo-controlled
Primary result
As reported in the abstract
Hazard ratio (95% CI)P value
FiO2 of 0.80 vs FiO2 of 0.30
1.46(0.79–2.70)
P = 0.23Antioxidants vs Placebo
0.98(0.54–1.80)
P = 0.96- Interaction FiO2 × antioxidants statistically significant; fatalities overrepresented with 80% oxygen and placebo
- P = 0.04
Further findings
One or more hospital admissions · 1 year
- Total with ≥1 hospital admission
- 260 (44%)
- No significant difference FiO2 0.80 vs 0.30
Myocardial infarction (MI) · 1 year
- Total with MI
- 7 (1.2%)
- No significant difference FiO2 0.80 vs 0.30
Original publication
Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1‐Year Follow‐Up of a Randomized Controlled Trial. Acta Anaesthesiol Scand. Published 7 October 2025. doi:10.
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