Perioperative medicine & outcomes
Effects of inhalation versus total intravenous anaesthesia on long-term mortality in older patients after noncardiac surgery: a retrospective observational study
Main finding · All-cause mortality within 1 yrResult — go to the resultHazard ratio 0.95 95% CI 0.84–1.08Authors' conclusion
The choice of anaesthetic agent during the intraoperative period was not associated with 1-yr mortality in older patients undergoing noncardiac surgery.
Study context
- Population
- Patients aged ≥60 yr undergoing noncardiac surgery under GA (≥2 h), January 2011 to June 2019
- Participants
- 45,879 patients
- Exposure
- Total intravenous anaesthesia (TIVA) vs inhalation anaesthesia for maintenance
- TIVAn = 7,273
- Inhalation anaesthesian = 38,606reference
- Outcome
- All-cause mortality
- Follow-up
- Within 1 yr after surgery
Methodological detailsstabilised inverse probability of treatment weighting
- Stabilised inverse probability of treatment weighting
Main finding
All-cause mortality within 1 yr · 1 yr
Hazard ratio
0.95
95% CI 0.84–1.08
TIVA vs inhalation anaesthesia for maintenance
HR 0.95 (95% CI 0.84–1.08)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
3-yr and 5-yr mortality
- Results similar to 1-yr mortality
1-yr mortality (subgroups: female patients, emergency surgery)
- Choice of anaesthetic agent showed differential effects on 1-yr mortality for female patients and emergency surgery
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| PPCs | 1.30 (1.22–1.37) | |
| Perioperative adverse cardiovascular events | 1.34 (1.22–1.48) | |
| AKI | 2.19 (1.88–2.57) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Effects of inhalation versus total intravenous anaesthesia on long-term mortality in older patients after noncardiac surgery: a retrospective observational study. Br J Anaesth. Published 5 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →