Perioperative medicine & outcomes
Glucose variability and mode of anaesthesia in major noncardiac surgery (GlucoVITAL): study protocol for a randomised controlled trial
Study context
- Population
- Participants ≥50 yr undergoing elective noncardiac surgeryplanned recruitment
- Participants
- 450 participants
- Planned comparison
- TIVA vs inhalation agents for maintenance of anaesthesia
- Primary endpoint
- Blood glucose at prespecified timepoints
- Follow-up
- Before, immediately after, and the morning after surgery
Methodological detailsmulticentre, parallel group, 1:1 allocation with minimisation, continuous glucose monitoring (CGM) (Dexcom G7) from induction for up to 10 days after surgery (or hospital discharge) to establish reliability and accuracy vs blood glucose, Secondary outcomes: DAOH within 30 days and postoperative complications (Clavien-Dindo grade ≥2)
- Multicentre
- Parallel group
- 1:1 allocation with minimisation
- CGM (Dexcom G7) from induction for up to 10 days after surgery (or hospital discharge) to establish reliability and accuracy vs blood glucose
- Secondary outcomes: DAOH within 30 days and postoperative complications (Clavien-Dindo grade ≥2)
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Glucose variability and mode of anaesthesia in major noncardiac surgery (GlucoVITAL): study protocol for a randomised controlled trial. BJA Open. Published 24 May 2025. doi:10.
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