Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial
Authors' conclusion
Resistance training with or without beta-hydroxy-beta-methylbutyrate during the entire hospitalisation intervention improves physical function and muscle strength in medical ICU patients, but muscle mass, quality of life, and 60-day mortality were unaffected.
Study context
- Population
- Adult medical ICU patients with internal medical diagnoses
- Participants
- 112 patients
- Comparison
- Resistance training, HMB, or combination vs standard care, from ICU to ward until discharge
- Primary endpoint
- 6MWD and SPPB
- Follow-up
- Discharge
Methodological detailsmulticentre, four-arm, single-blind
- Multicentre
- Four-arm
- Single-blind
Primary result
As reported in the abstract
SPPB and 6MWD
- Resistance training
- Short physical performance battery (SPPB) increase 3.848 points; P < 0.01
- Combination
- SPPB increase 2.832 points; P < 0.01
- Resistance training
- 6MWD improvement 99.768 m; P < 0.01
- Combination
- 6MWD improvement 88.577 m; P < 0.01
Secondary outcomes
Muscle strength (MRC, grip strength) at ICU and hospital discharge
- Significant improvements in the resistance training and combination groups
- P < 0.05
60-day mortality, intensive care unit-acquired weakness (ICU-AW) prevalence, muscle mass, quality of life, other functional aspects
- No significant differences between treatment groups and usual care
Original publication
Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial. Crit Care. Published 15 December 2023. doi:10.
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