Effects of neuromuscular block reversal with neostigmine/glycopyrrolate versus sugammadex on bowel motility recovery after laparoscopic colorectal surgery: A randomized controlled trial
Authors' conclusion
The time to the first flatus was shorter using 2 mg.kg-1 sugammadex to reverse the neuromuscular block for laparoscopic colorectal surgery compared to reversal with conventional neostigmine/glycopyrrolate.
Study context
- Population
- Patients undergoing laparoscopic colorectal surgery
- Participants
- 111 patients
- Comparison
- NMB reversal with sugammadex vs neostigmine/glycopyrrolate
- Primary endpoint
- Time from end of surgery to first flatus
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Time to first flatus
P = 0.027
Further findings
Time to first defecation, PONV, ileus, postoperative LOS
- Did not differ between the groups
Safety
Postoperative dry mouth · significantly lower with sugammadex
P < 0.001
Original publication
Effects of neuromuscular block reversal with neostigmine/glycopyrrolate versus sugammadex on bowel motility recovery after laparoscopic colorectal surgery: A randomized controlled trial. J Clin Anesth. Published 21 August 2024. doi:10.
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