Effects of different veno-venous (VV) extracorporeal membrane oxygenation (ECMO) blood flow rates on lung perfusion assessment by hypertonic saline bolus-based electrical impedance tomography
Authors' conclusion
During VV ECMO, the ECMO blood flow rate, closely linked to recirculation fraction, could affect the accuracy of lung perfusion assessment using hypertonic saline bolus-based EIT.
Study context
- Population
- Patients on VV ECMO meeting ECMO weaning criteria
- Participants
- 15 patients
- Exposure
- ECMO blood flow rates decreased stepwise from 4.5 L/min to 3.5, 2.5, 1.5 and 0 L/min
- Outcome
- Lung perfusion distribution by saline bolus-based electrical impedance tomography (EIT) (4.5 vs 0 L/min)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Median lung perfusion in region-of-interest (ROI) 2: 38.21 (34.93-42.16)% to 41.29 (35.32-43.75)%, significantly increased
- p = 0.003
- Median lung perfusion in ventral region: 48.86 (45.53-58.96)% to 54.12 (45.07-61.16)%, significantly increased
- p = 0.037
- Median lung perfusion in ROI 4: 7.87 (5.42-9.78)% to 6.08 (5.27-9.34)%, significantly decreased
- p = 0.049
- Median lung perfusion in dorsal region: 51.14 (41.04-54.47)% to 45.88 (38.84-54.93)%, significantly decreased
- p = 0.037
Observational data: associations, not effects.
Further findings
Recirculation fraction
- Decreased significantly as ECMO blood flow decreased from 4.5 to 0 L/min
Original publication
Effects of different VV ECMO blood flow rates on lung perfusion assessment by hypertonic saline bolus-based electrical impedance tomography. Crit Care. Published 17 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →