Neuroanesthesia & neurocritical care
Effects of Early Versus Delayed Mechanical Thrombectomy on Outcomes in Intermediate-Risk Acute Pulmonary Embolism
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.80 95% CI 0.82–3.95Authors' conclusion
In patients presenting with intermediate-risk PE, timing of mechanical thrombectomy did not influence in-hospital mortality.
Study context
- Population
- Patients with intermediate-risk pulmonary embolism (PE) treated with mechanical thrombectomy
- Participants
- 290 patients
- Exposure
- Early vs delayed mechanical thrombectomy
- Early intervention (EI)n = 179
- Delayed intervention (DI)n = 111reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, five academic hospitals, generalized estimated equation
- Multicentre
- Five academic hospitals
- Generalized estimated equation
Main finding
As reported in the abstract
Odds ratio
1.80
95% CI 0.82–3.95
P = 0.14
Events by group
Timing of intervention
odds ratio 1.80 (95% CI 0.82–3.95); P = 0.14
Observational data: associations, not effects.
Further findings
Intubation
P = 0.028
| Outcome | EI | DI | P value |
|---|---|---|---|
| Reduction in pulmonary artery systolic pressure | −25.8% (SD 17.0) | −18.9% (SD 17.1) | P = 0.020 |
| Reduction in mean pulmonary artery pressure | −26.8% (SD 17.7) | −20.2% (SD 19.7) | P = 0.016 |
Original publication
Effects of Early Versus Delayed Mechanical Thrombectomy on Outcomes in Intermediate-Risk Acute Pulmonary Embolism. Crit Care Med. Published 23 April 2026. doi:10.
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