ICU sedation, delirium & recovery

Effects of morning versus afternoon surgery on peri‐operative disturbance of sleep–wake timing: An observational study

Acta Anaesthesiol ScandPublished Prospective observational study

Authors' conclusion

Our results suggest that the timing of surgery between 08:00 h and 17:00 h does not modulate the effect of anaesthesia and surgery on phase of the sleep-wake rhythm in patients undergoing elective surgery with a low pre-operative risk of delirium.

Study context

Population
Adults (≥18 years) undergoing elective surgery
Participants
259 adults
Exposure
Morning vs afternoon surgery
  • Morningn = 144reference
  • Afternoonn = 115
Outcome
Post-operative midpoint of sleep shift between morning and afternoon surgery (daily sleeping log)
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Midpoint of sleep shift, night after surgery vs 3 nights before · night after surgery
GroupValuep
Morningmean - 00:41 (95% CI −00:27 h to −00:54 h) hp < .001
Afternoonmean - 00:28 (95% CI −00:09 h to −00:46 h) hp = .003

Value

Morningmean - 00:41 (95% CI −00:27 h to −00:54 h) h
Afternoonmean - 00:28 (95% CI −00:09 h to −00:46 h) h

p

Morningp < .001
Afternoonp = .003
No between-group difference in midpoint of sleep shift (mean - 00:13 h, 95% CI −00:35 h-00:09 h)
P = 0.25

Observational data: associations, not effects.

Secondary outcomes

Reduction of sleep quality

Similar in the two groups

Factors affecting phase advance

Larger phase advance with evening chronotype or lower pre-operative sleep quality

Factors affecting decline of sleep quality after surgery

Larger decline with evening chronotype, longer procedures or better pre-operative sleep quality

Original publication

Effects of morning versus afternoon surgery on peri‐operative disturbance of sleep–wake timing: An observational study. Acta Anaesthesiol Scand. Published 17 November 2024. doi:10.1111/aas.14543

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