Effects of remimazolam on hemodynamic changes during cardiac ablation for atrial fibrillation under general anesthesia: a propensity-score-matched retrospective cohort study
Authors' conclusion
General anesthesia using remimazolam vs desflurane was associated with significantly reduced vasoactive agent requirement and better hemodynamic stability without increased postoperative complications in patients undergoing ablation for atrial fibrillation.
Study context
- Population
- Adults undergoing ablation for AF under GA, July 2021–July 202278 per group after propensity-score matching (PSM)
- Participants
- 177 adults
- Exposure
- Remimazolam vs desflurane as principal anaesthetic agent
- Remimazolamn = 78
- Desfluranen = 99reference
- Outcome
- Overall incidence of vasoactive agent use
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Incidence rate, duration and maximum dose of continuous vasopressor infusionSignificantly lower with remimazolam | P < 0.001 |
Safety
Complications after ablation
- Remimazolam not associated with increased complications
Original publication
Effects of remimazolam on hemodynamic changes during cardiac ablation for atrial fibrillation under general anesthesia: a propensity-score-matched retrospective cohort study. Can J Anaesth. Published 10 July 2023. doi:10.
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