Cardiac arrest & resuscitation
Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial
Primary result · Poor functional outcome (mRS 4–6), very early hyperoxemiaResult — go to the resultOdds ratio 1.63 95 % CI 1.08–2.44Authors' conclusion
Very early hyperoxemia after ICU admission is associated with higher risk of poor functional outcome after OHCA.
Study context
- Population
- Patients resuscitated after out-of-hospital cardiac arrest (OHCA) admitted to the intensive care unit (ICU)1,591 analysed for late period
- Participants
- 1,631 patients
- Comparison
- PaO2 >245 mmHg vs ≤245 mmHg in the very early period
- Primary endpoint
- Poor functional outcome (modified Rankin Score (mRS) 4 to 6), by highest PaO2 cut-off in the 'very early' (0-4 h), 'early' (8-24 h) and 'late' (28-72 h) periods
- Follow-up
- 6 months
Primary result
As reported in the abstract
Poor functional outcome (mRS 4–6), very early hyperoxemia
Odds ratio
1.63
95 % CI 1.08–2.44
P = 0.019
PaO2 >245 mmHg vs PaO2 ≤245 mmHg
OR 1.63 (95 % CI 1.08–2.44); P = 0.019
Original publication
Effects of very early hyperoxemia on neurologic outcome after out-of-hospital cardiac arrest: A secondary analysis of the TTM-2 trial. Resuscitation. Published 7 December 2024. doi:10.
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