Effects of Sevoflurane Inhalation on Pulmonary Hemodynamics in Moderate to Severe Acute Respiratory Distress Syndrome Patients With Septic Shock: A Prospective Cohort Study
Authors' conclusion
In mechanically ventilated moderate to severe ARDS patients receiving lung protective ventilation, sevoflurane inhalation was not associated with decreases in mPAPs and PVRs.
Study context
- Population
- Deeply sedated, intubated adults with moderate to severe acute respiratory distress syndrome (ARDS) (PaO2/FiO2 <150 mm Hg, PEEP ≥5 cm H2O) and septic shock monitored with a pulmonary arterial catheter, medical ICU of a university teaching hospitalinterim analysis
- Participants
- 15 participants
- Exposure
- Sevoflurane inhalation vs before
- Outcome
- Change in mean pulmonary arterial pressure (mPAP) between T0 and H + 1
- Follow-up
- 1 hour
Methodological detailssingle-group before–after, single-centre, Smaller than planned sample size
- Single-group before–after
- Single-centre
- Smaller than planned sample size
Main finding
As reported in the abstract
mPAP
Observational data: associations, not effects.
Secondary outcomes
| Outcome | H + 1 | H + 12-18 |
|---|---|---|
| mPAP · 12-18 hours | — not stated in the abstract | 23 ± 6 mm Hg |
| Mean expired fraction of sevoflurane | mean 0.75% ± 0.25% | mean 0.71% ± 0.25% |
— not stated in the abstract
Mean pulmonary arterial pressure (mPAP) · 12-18 hours
- Unchanged vs inclusion
PVR indexed (PVRI), cardiac index, MAP, pulmonary shunt · H + 1 and H + 12-18
- No significant variations
PaO2/FiO2, patients remaining in supine position (subgroup) · H + 12-18
- Improved from 158 ± 49 to 249 ± 86 mm Hg
- P = 0.015
PaO2/FiO2, patients turned prone (subgroup) · H + 12-18
- Improved from 134 ± 36 to 241 ± 109 mm Hg
- P = 0.018
Original publication
Effects of Sevoflurane Inhalation on Pulmonary Hemodynamics in Moderate to Severe Acute Respiratory Distress Syndrome Patients With Septic Shock: A Prospective Cohort Study. Crit Care Med. Published 16 June 2025. doi:10.
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