Respiratory failure & ventilation
Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial
Primary resultResult — go to the resultProportional OR 0.72 95% CI 0.39–1.32- stopped early for recruitment fatigue
- Trial stopped because of recruitment fatigue after 214 patients were randomised
Authors' conclusion
In patients with moderate to severe ARDS secondary to community-acquired pneumonia, a driving pressure-limiting strategy did not increase the number of ventilator-free days compared with a standard low PEEP strategy within 28 days.
Study context
- Population
- Adults with moderate to severe acute respiratory distress syndrome (ARDS) secondary to community-acquired pneumonia198 analysed
- Participants
- 214 adults
- Comparison
- Driving pressure-limiting strategy vs low positive end-expiratory pressure (PEEP) strategy
- Driving pressure-limiting strategyn = 96
- Low PEEP strategyn = 102reference
- Primary endpoint
- Ventilator-free days
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Proportional OR
0.72
95% CI 0.39–1.32
P = 0.28
By group
Driving pressure-limiting strategy vs Low PEEP strategy
proportional OR 0.72 (95% CI 0.39–1.32); P = 0.28
Secondary outcomes
Driving pressure up to day 3
- Mean difference in driving pressure, intervention vs control
- −0.7 cm H2O (95% CI −1.4 to −0.1 cm H2O)
In-hospital and ICU mortality · 90 days
- No significant differences regarding secondary outcomes
Original publication
Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial. Br J Anaesth. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →