Perioperative medicine & outcomes
Effects of tidal volume challenge on the reliability of plethysmography variability index in hepatobiliary and pancreatic surgeries: a prospective interventional study
Authors' conclusion
In hepatobiliary and pancreatic surgeries, tidal volume challenge improves the reliability of PVI for predicting fluid responsiveness and changes in PVI values obtained after tidal volume challenge are comparable to the changes in SVI.
Study context
- Population
- Adults undergoing hepatobiliary or pancreatic tumour resections with controlled low VT ventilation
- Exposure
- ΔPVI after VT challenge for predicting fluid responsiveness
- Outcome
- Prediction of fluid responsiveness (SVI rise ≥ 10% after crystalloid bolus 6 ml kg- 1 over 10 min) by ΔPVI6-8
Methodological detailsdiagnostic accuracy (ROC analysis)
- Diagnostic accuracy (ROC analysis)
Main finding
As reported in the abstract
Prediction of fluid responsiveness
| Group | AUC | Sensitivity | Specificity | Best cut-off (absolute change) |
|---|---|---|---|---|
| ΔPVI6-8 | 0.86 (95% CI 0.76-0.96), P < 0.001 | 95% | 68% | 2.5% |
ΔPVI6-8
AUC0.86 (95% CI 0.76-0.96), P < 0.001
Sensitivity95%
Specificity68%
Best cut-off (absolute change)2.5%
Observational data: associations, not effects.
Original publication
Effects of tidal volume challenge on the reliability of plethysmography variability index in hepatobiliary and pancreatic surgeries: a prospective interventional study. J Clin Monit Comput. Published 18 March 2023. doi:10.
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