Effects of Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Postoperative Pain and Side Effects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
As a novel technique, the TTP block exhibited a superior postoperative analgesic effect during the early postoperative period.
Study context
- Population
- Surgical patients in clinical studies of TTP block analgesia
- Participants
- 682 patients · 11 randomized controlled trials (RCTs)
- Comparison
- Ultrasound-guided TTP block vs no block
- Outcome
- Postoperative pain scores at rest and during movement, morphine consumption in 24 h, and postoperative nausea and vomiting (PONV) rate
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
TTP block vs No blockMD (95% CI)
Pain score at 0 h, at rest
−2.28(−2.67 to −1.90)
Pain score at 0 h, during movement
−2.09(−2.62 to −1.56)
Pain score at 12 h, at rest
−1.42(−2.03 to −0.82)
Pain score at 12 h, during movement
−2.13(−2.80 to −1.46)
24-h postoperative analgesic consumption
−23.18(−33.71 to −12.66)
TTP block vs No blockOdds ratio (95% CI)
Incidence of PONV
0.36(0.15–0.88)
Further pooled results
24-h postoperative analgesic consumption (trial sequential analysis)
- Trial sequential analysis confirmed less 24-h analgesic consumption with TTP block
Original publication
Effects of Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Postoperative Pain and Side Effects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. Published 5 November 2022. doi:10.
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