Effects of vasopressor dose on microcirculation despite preserved macrohemodynamic targets in septic shock: a prospective observational study
Main finding · StO2 recovery slope vs norepinephrine-equivalent doseResult — go to the resultrho −0.728Authors' conclusion
Higher norepinephrine-equivalent dose was associated with lower dynamic microvascular reactivity despite preserved MAP and ScvO2. Preserved ScvO2 did not track dynamic VOT-derived microvascular reserve.
Study context
- Population
- Mechanically ventilated adults with septic shock receiving vasopressors, after initial resuscitation to mean arterial pressure (MAP) ≥65 mmHg
- Participants
- 30 participants
- Exposure
- Higher vs lower norepinephrine-equivalent dose
- Outcome
- Thenar near-infrared spectroscopy (NIRS) vascular occlusion test microvascular indices: StO2 recovery slope and StO2 hyperemia AUC
- Follow-up
- After initial hemodynamic resuscitation
Main finding
As reported in the abstract
StO2 recovery slope vs norepinephrine-equivalent dose
rho
−0.728
P < 0.001
Observational data: associations, not effects.
Further findings
ScvO2 vs dynamic vascular occlusion testing (VOT)-derived indices
- ScvO2 not associated with dynamic VOT-derived indices after correction for multiple comparisons
28-day mortality prognosis (exploratory ROC)
- Saturation (StO2) hyperemia AUC and recovery slope showed exploratory prognostic signal
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of vasopressor dose on microcirculation despite preserved macrohemodynamic targets in septic shock: a prospective observational study. J Crit Care. Published 24 September 2026. doi:10.
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