Mean arterial pressure-to-norepinephrine-equivalent dose ratio, rather than achieved mean arterial pressure alone, is associated with mortality in septic shock
Authors' conclusion
Higher achieved MAP was not independently associated with 28-day mortality after accounting for vascular responsiveness.
Study context
- Population
- Adults with septic shock receiving vasopressors within 24 h of ICU admissionMIMIC-IV 4944
- Participants
- 7,433 adults
- Exposure
- 24-h time-weighted average mean arterial pressure (MAP) ≥ 80 mmHg vs 65-80 mmHg
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailstwo independent critical care databases (MIMIC-IV and eICU), mediation analysis
- Two independent critical care databases (MIMIC-IV and eICU)
- Mediation analysis
Main finding
As reported in the abstract
28-day mortality
eICU
- MAP ≥ 80 mmHg vs MAP 65-80 mmHg: P < 0.001 — both cohorts
Observational data: associations, not effects.
Further findings
MAP/NEQ and 28-day mortality
- MAP/NEQ independently and inversely associated with mortality in both cohorts; AUC MIMIC-IV
- 0.81
- AUC eICU
- 0.72
Mediation analysis (suppression effect)
- Suppression effect, MIMIC-IV
- - 33%
- Suppression effect, eICU
- - 26%
Subgroup and sensitivity analyses
- Consistent
Original publication
Mean arterial pressure-to-norepinephrine-equivalent dose ratio, rather than achieved mean arterial pressure alone, is associated with mortality in septic shock. J Intensive Care. Published 13 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →