ICU sedation, delirium & recovery
Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial
Authors' conclusion
Ciprofol was well tolerated, with a noninferior sedation profile to propofol in Chinese ICU patients undergoing MV for a period of 6-24 hours.
Study context
- Population
- ICU patients 18 to 80 years old, intubated and undergoing mechanical ventilation (MV), expected to require sedation for 6–24 hours; 21 centres in China129 completed
- Participants
- 135 patients
- Comparison
- Ciprofol vs propofol sedation
- Ciprofoln = 90
- Propofoln = 45reference
- Primary endpoint
- Sedation success rate
Methodological detailsmulticentre, single-blind, non-inferiority
- Multicentre
- Single-blind
- Non-inferiority
Primary result
As reported in the abstract
Secondary outcomes
| Outcome | P value |
|---|---|
| Recovery timeLonger with ciprofol | P = 0.003 |
Remaining secondary endpoints
- No differences (all p > 0.05)
Safety
Treatment-emergent adverse events (TEAEs) and drug-related TEAEs
- Not significantly different between groups (all p > 0.05)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial. Crit Care Med. Published 5 June 2023. doi:10.
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