Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial
Authors' conclusion
Expanded periurethral cleansing could reduce the incidence of CAUTI, especially those caused by bacteria and multiple pathogens, in comatose patients with short-term catheterization (≤ 10 days).
Study context
- Population
- Comatose patients with urinary catheter
- Participants
- 225 vs 221
- Comparison
- Expanded vs usual periurethral cleansing protocol
- Experimentaln = 225
- Controln = 221reference
- Primary endpoint
- Incidence of CAUTI
- Follow-up
- Days 3, 7, and 10 after catheter insertion
Primary result
As reported in the abstract
CAUTI · day 10
P = 0.001
Further findings
CAUTI · day 3
P = 0.54
CAUTI · day 7
P = 0.24
Bacterial CAUTI
P = 0.02
Fungal CAUTI
P = 0.38
Polymicrobial CAUTI
P = 0.03
CAUTI in females (subgroup)
P < 0.05
CAUTI in patients with diabetes (subgroup)
P < 0.05
- Catheter-associated urinary tract infection (CAUTI) in females (subgroup): 13/132 vs 31/105
- CAUTI in patients with diabetes (subgroup): 14/79 vs 29/71
Pathogens
- Escherichia coli and Candida albicans most common species in both groups
Original publication
Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial. Crit Care. Published 13 May 2024. doi:10.
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