Efficacy of long-acting local anesthetics versus their mixture with shorter-acting local anesthetics for peripheral nerve blocks guided by ultrasound: a systematic review with meta-analysis of randomized controlled trials
Pooled result · Sensory block onsetResult — go to the resultMD −1.62 min 95% CI −4.04 to 0.81Authors' conclusion
LA mixtures may not affect sensory and motor block onset in ultrasound-guided PNB but could shorten the duration of sensory blockade.
Study context
- Population
- Patients receiving ultrasound-guided peripheral nerve blocks
- Participants
- 516 patients · 10 randomized controlled trials (RCTs)
- Comparison
- Mixture of local anesthetic (LA) vs Long-acting LA
- Outcome
- Sensory block onset
Methodological detailsrandom-effects meta-analysis, risk of bias (RoB) 2.0, sensitivity analyses, GRADE, Searched WoS, Scopus, MEDLINE, EMBASE, BVS/LILACS and Cochrane, 1998 to 2024
- Random-effects meta-analysis
- RoB 2.0
- Sensitivity analyses
- GRADE
- Searched WoS, Scopus, MEDLINE, EMBASE, BVS/LILACS and Cochrane, 1998 to 2024
Pooled result
As reported in the abstract
MD
−1.62 min
95% CI −4.04 to 0.81
Mixture of LA vs Long-acting LA
MD −1.62 min (95% CI −4.04 to 0.81)
Further pooled results
| Outcome | MD (min) (95% CI) | |
|---|---|---|
| Motor block onsetI2=98.89%; PI=−31.90 to 20.69 · very low certainty | −5.60 (−14.54 to 3.33) | |
| −20−10010Difference, min (linear scale) |
| Outcome | MD (hours) (95% CI) | |
|---|---|---|
| Duration of sensory blockI2=90.77%; PI=−7.24 to 2.92 · very low certainty | −2.16 (−4.16 to −0.17) | |
| −6−4−202Difference, hours (linear scale) |
Original publication
Efficacy of long-acting local anesthetics versus their mixture with shorter-acting local anesthetics for peripheral nerve blocks guided by ultrasound: a systematic review with meta-analysis of randomized controlled trials. Reg Anesth Pain Med. Published 8 January 2025. doi:10.
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