Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy: a double-blinded, randomised, placebo-controlled trial
An erratum to this article was published (Br J Anaesth, Dec 2025 ↗)
Authors' conclusion
Prolonged intravenous lidocaine infusion reduced the incidence of moderate-to-severe movement-evoked pain for 48 h after hepatectomy.
Study context
- Population
- Patients undergoing elective hepatectomyenrolled
- Participants
- 260 patients
- Comparison
- Prolonged i.v. lidocaine infusion vs placebo
- Primary endpoint
- Incidence of moderate-to-severe movement-evoked pain
- Follow-up
- 24 h postoperatively
Methodological detailsdouble-blinded, placebo-controlled
- Double-blinded
- Placebo-controlled
Primary result
As reported in the abstract
Moderate-to-severe movement-evoked pain · 24 h
P = 0.001
Secondary outcomes
Moderate-to-severe movement-evoked pain · 48 h
P = 0.001
PPCs
P = 0.007
| Outcome | Lidocaine | Placebo | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Movement-evoked pain scores · 24 hBelow the minimal clinically important difference | 3.7 (SD 1.7) | 4.2 (SD 1.6) | 0.5 (0.1–0.9) | P = 0.018 | |
| −0.500.51Difference (linear scale) |
mg
| Outcome | Lidocaine | Placebo | Mean difference (mg) (95% CI) | P value | |
|---|---|---|---|---|---|
| Morphine equivalent consumption · 24 hBelow the minimal clinically important difference | 47.2 (SD 16.7) | 52.6 (SD 19.2) | 5.4 (1.0–9.8) | P = 0.016 | |
| −50510Difference, mg (linear scale) |
Safety
- Plasma lidocaine concentration (after bolus, end of surgery, 24 h postoperatively) — Lidocaine
- median 1.5 (IQR 1.1–2.1) μg ml-1
- Plasma lidocaine concentration (after bolus, end of surgery, 24 h postoperatively): Lidocaine median 1.9 (IQR 1.4–2.6) μg ml-1
- Plasma lidocaine concentration (after bolus, end of surgery, 24 h postoperatively): Lidocaine median 1.1 (IQR 0.8–1.6) μg ml-1
- Plasma lidocaine concentration (after bolus, end of surgery, 24 h postoperatively): values after bolus injection, at end of surgery, and 24 h postoperatively, respectively
Original publication
Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy: a double-blinded, randomised, placebo-controlled trial. Br J Anaesth. Published 16 May 2023. doi:10.
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