Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultRelative risk 0.94 95% CI 0.77–1.14Authors' conclusion
TDM-based regimens had no significant efficacy for clinical or pharmacological outcomes.
Study context
- Population
- Critically ill patients
- Participants
- 1,011 patients · 5 studies
- Comparison
- Therapeutic drug monitoring (TDM)-based antibiotic regimen vs control
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsCochrane risk of bias tool version 2, GRADE certainty assessment
- Cochrane risk of bias tool version 2
- GRADE certainty assessment
Pooled result
As reported in the abstract
Relative risk
0.94
95% CI 0.77–1.14
TDM-based regimen vs Control
RR 0.94 (95% CI 0.77–1.14)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| In-hospital mortalityNot significantly different; low or very low certainty | 0.96 (0.76–1.20) | |
| Clinical cureNot significantly different; low or very low certainty | 1.23 (0.91–1.67) | |
| Target attainment · day 1Not significantly different; low or very low certainty | 1.14 (0.88–1.48) | |
| Target attainment · day 3Not significantly different; low or very low certainty | 1.35 (0.90–2.03) | |
| 0.512Relative risk (log scale) |
| Outcome | Mean difference (95% CI) |
|---|---|
| ICU LOSNot significantly different; low or very low certainty | 0 (- 2.18-2.19) |
Original publication
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials. J Intensive Care. Published 8 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →