Efficiency of dosing software using Bayesian forecasting in achieving target antibiotic exposures in critically ill patients, a prospective cohort study
Authors' conclusion
The use of TDM combined with Bayesian forecasting dosing software increases the efficiency for achieving target antibiotic exposures in the ICU.
Study context
- Population
- Adult intensive care unit (ICU) patients prescribed vancomycin, piperacillin-tazobactam or meropenem with subtherapeutic or supratherapeutic exposure on therapeutic drug monitoring (TDM)included in the analysis
- Participants
- 70 patients
- Outcome
- Target antibiotic exposure achieved on repeat TDM
Methodological detailssingle-group, March 2020 to December 2021
- Single-group
- March 2020 to December 2021
Main finding
As reported in the abstract
Target antibiotic exposure achieved after one software recommendation
Patients achieving target exposures after one software recommendation (of 50 with repeated measurements)
43
86%
Patients achieving target exposures after 2 recommendations (of remaining 7)
3
Observational data: associations, not effects.
Secondary outcomes
- Patients achieving clinical cure (of 50)
- 47 (94%)
Safety
- No antibiotic exposure-related adverse events reported
Original publication
Efficiency of dosing software using Bayesian forecasting in achieving target antibiotic exposures in critically ill patients, a prospective cohort study. Anaesth Crit Care Pain Med. Published 12 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →