International survey of antibiotic dosing and monitoring in adult intensive care units
Authors' conclusion
We observed numerous changes in practice since the ADMIN-ICU 2015 survey was conducted. Beta-lactams are more commonly administered as extended infusions, and therapeutic drug monitoring use has increased, which align with emerging evidence.
Study context
- Population
- Respondents (physicians and pharmacists) from adult ICUs; dosing, administration and monitoring of vancomycin, piperacillin/tazobactam, meropenem and aminoglycosides
- Participants
- 538 respondents · 409 hospitals · 45 countries
- Outcome
- Antibiotic dosing, administration and monitoring practices
Methodological detailsinternational survey, 71% physicians and 29% pharmacists
- International survey
- 71% physicians and 29% pharmacists
Main finding
As reported in the abstract
- Vancomycin loading doses used
- 74%
- Most favoured vancomycin loading dose, intermittent infusion
- 25 mg/kg
- Most favoured vancomycin loading dose, continuous infusion
- 20 mg/kg
- Piperacillin/tazobactam administered as extended infusion
- 42%
- Meropenem administered as extended infusion
- 51%
- Therapeutic drug monitoring, vancomycin
- 90%
- Therapeutic drug monitoring, aminoglycosides
- 82%
- Therapeutic drug monitoring, piperacillin/tazobactam
- 43%
- Therapeutic drug monitoring, meropenem
- 39%
- Dosing software use, vancomycin (most frequent)
- 11%
Observational data: associations, not effects.
Original publication
International survey of antibiotic dosing and monitoring in adult intensive care units. Crit Care. Published 19 June 2023. doi:10.
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