Respiratory failure & ventilation
Electrical Impedance Tomography for Real-Time Positive End-expiratory Pressure (PEEP) Monitoring and Atelectasis During Mask Ventilation: A Randomized Controlled Physiological Trial
Authors' conclusion
Using real-time bedside EIT our study demonstrates that higher PEEP levels during mask ventilation at anesthesia induction can improve ventilation distribution without adverse hemodynamic effects.
Study context
- Population
- Adults undergoing elective ophthalmic surgery under GAcrossover of PEEP levels
- Participants
- 72 adults
- Comparison
- 8 mbar vs 0 mbar
- Primary endpoint
- Occurrence and degree of atelectasis represented by the dorsoventral ventilation gradient at each PEEP level, detected by electrical impedance tomography (EIT)
Methodological detailsprospective, physiological, randomised ascending or descending PEEP sequence
- Prospective
- Physiological
- Randomised ascending or descending PEEP sequence
Primary result
As reported in the abstract
Dorsoventral ventilation gradient (dimensionless)
0 mbar
0.48
mean · SD 0.21
5 mbar
0.56
mean · SD 0.28
8 mbar
0.63
mean · SD 0.25
P < 0.001
Secondary outcomes
Mean
| Outcome | 0 mbar | 5 mbar | 8 mbar | P value |
|---|---|---|---|---|
| EELI gain/loss ratio, whole lung (dimensionless)8 mbar vs 0 mbar · across PEEP levels | 3.1 (SD 4.8) | 6.1 (SD 8.1) | 10.5 (SD 12.2) | P < 0.001 |
| Compliance gain/loss ratio, whole lung (dimensionless)8 mbar vs 0 mbar · across PEEP levels | 2.7 (SD 9.2) | 3.8 (SD 10.3) | 4.3 (SD 11.3) | P = 0.011 |
- End-expiratory lung impedance (EELI) gain/loss ratio, whole lung (dimensionless): 5 mbar ≈5.1 cmH2O; 8 mbar ≈8.2 cmH2O
Safety
Hemodynamic parameters (electrical cardiometry)
- Decreased after induction, not associated with specific PEEP levels
Original publication
Electrical Impedance Tomography for Real-Time PEEP Monitoring and Atelectasis During Mask Ventilation: A Randomized Controlled Physiological Trial. Anesth Analg. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →