Respiratory failure & ventilation
Electrical impedance tomography-guided positive end-expiratory pressure (PEEP) and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial
- terminated early for futility
Authors' conclusion
In patients with moderate to severe ARDS, EIT-guided PEEP did not significantly reduce 28-day mortality compared with the lower PEEP/FiO2 table strategy.
Study context
- Population
- Adults with moderate to severe acute respiratory distress syndrome (ARDS), 5 sites in China, February 2022 to June 2023all completed follow-up
- Participants
- 190 adults
- Comparison
- Electrical impedance tomography (EIT)-guided PEEP vs lower PEEP/FiO2 table
- Primary endpoint
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsmulticentre, pre-planned interim analysis
- Multicentre
- Pre-planned interim analysis
Primary result
As reported in the abstract
Hazard ratio
0.96
95% CI 0.65–1.41
P = 0.821
Events by treatment group
EIT-guided PEEP vs Lower PEEP/FiO2 table
HR 0.96 (95% CI 0.65–1.41); P = 0.821
Further findings
| Outcome | EIT-guided PEEP | Lower PEEP/FiO2 table | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| 28-day mortality, patients with higher lung recruitability (recruitment-inflation ratio) (subgroup) | 35.6% · 16 of 45 | 60.0% · 27 of 45 | 0.49 (0.26–0.91) | P = 0.024 | |
| 0.20.5125Hazard ratio (log scale) |
PEEP levels during the first 7 days
- PEEP levels didn't differ between groups (difference in marginal means 0.2 [SE 0.1]; P = .187)
Ventilator-free days and other secondary clinical outcomes
- Did not differ
Safety
Safety outcomes
- Did not differ between groups
Original publication
Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial. Am J Respir Crit Care Med. Published 23 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →