Respiratory failure & ventilation
Electric impedance tomography-guided positive end-expiratory pressure (PEEP) titration reduces mechanical power in ARDS: a randomized crossover pilot trial
Primary result · Mechanical powerResult — go to the resultMean difference - 4.36 J/min 95% CI - 6.7, - 1.95Authors' conclusion
In patients with moderate-severe acute respiratory distress syndrome, EIT-guided PEEP titration reduces mechanical power mainly through a reduction in elastic-dynamic power.
Study context
- Population
- Patients with moderate-severe ARDS on mechanical ventilation
- Comparison
- Electric impedance tomography (EIT)-guided PEEP selection vs High-PEEP/FiO2 table
- Primary endpoint
- Change in mechanical power after each PEEP selection strategy
Methodological detailscrossover, pilot, single-centre
- Crossover
- Pilot
- Single-centre
Primary result
Mechanical power
Mean difference
- 4.36 J/min
95% CI - 6.7, - 1.95
P = 0.002
As reported in the abstract
Secondary outcomes
| Outcome | Estimate | P value |
|---|---|---|
| 4ΔP + RR index | difference - 11.42 J/min (95% CI - 19.01, - 3.82) | P = 0.007 |
| Elastic-dynamic power | difference - 1.61 J/min (CI - 2.99, - 0.22) | P = 0.027 |
| Set PEEP | change - 2 cmH2O | P = 0.046 |
| Driving pressure | change - 2.92 cmH2O | P = 0.003 |
| Peak pressure | change - 6.25 cmH2O | P = 0.003 |
| Plateau pressure | change - 4.53 cmH2O | P = 0.006 |
| Static respiratory system compliance | change + 7.93 ml/cmH2O | P = 0.008 |
Elastic-static and resistive powers
- Unchanged
Original publication
Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial. Crit Care. Published 17 January 2023. doi:10.
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