Respiratory failure & ventilation
Electrical impedance tomography-guided positive end-expiratory pressure titration in acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis
Authors' conclusion
EIT facilitates real-time, individualized PEEP adjustments, improving respiratory system mechanics.
Study context
- Population
- ARDS patients; literature January 2012 to May 202313 studies (3 RCTs)
- Participants
- 623 patients
- Comparison
- EIT-guided positive end-expiratory pressure (PEEP) titration vs conventional methods
- Outcome
- Respiratory mechanics and mechanical power
Methodological detailsrandom-effects models, sensitivity analysis
- Random-effects models
- Sensitivity analysis
Pooled result
As reported in the abstract
EIT-guided PEEP vs Conventional methodsMD (95% CI)
Lung compliance; n = 941 cases
4.33(2.94–5.71)
MD -
- Mechanical power; n = 148
- 1.99 (95% CI - 3.51, - 0.47)
- Driving pressure; n = 903
- 1.20 (95% CI - 2.33, - 0.07)
Further pooled results
| Outcome | MD (95% CI) | |
|---|---|---|
| Lung compliance, randomised trials vs non-randomised studies (sensitivity analysis)Trend towards improvement · sensitivity analysis | 2.43 (- 0.39 to 5.26) | |
| −50510Difference (linear scale) |
Mortality
- Reduction in mortality rate associated with modest improvements in compliance and driving pressure (3 studies, 259 patients), RR
- 0.64 (95% CI 0.45–0.91)
- Three studies
Original publication
Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. Published 21 March 2024. doi:10.
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