Respiratory failure & ventilation
Electrical impedance tomography to set high pressure in time-controlled adaptive ventilation
Authors' conclusion
EIT enabled detection of regional ventilation distribution on TCAV during a decremental Phigh trial and thus enabled the determination of a best EIT-derived-Phigh through an individualized approach, achieving best compromise between overdistension and collapse.
Study context
- Population
- Patients with moderate or severe ARDS ventilated with TCAV (APRV mode), 2023
- Participants
- 11 patients
- Exposure
- Phigh levels 34 to 18 cmH2O on TCAV, electrical impedance tomography (EIT)-monitored
- Outcome
- Best EIT-derived Phigh (crossing point between overdistension and collapse curves)
Methodological detailssingle-center, decremental Phigh trial, Driving pressure kept constant by adjusting Tlow, EIT monitoring with PulmoVista 500
- Single-center
- Decremental Phigh trial
- Driving pressure kept constant by adjusting Tlow
- EIT monitoring with PulmoVista 500
Main finding
As reported in the abstract
Best EIT-derived Phigh
- Best EIT-derived Phigh 18 cmH2O
- four patients
- Best EIT-derived Phigh 22 cmH2O
- five patients
- Best EIT-derived Phigh 26 cmH2O
- two patients
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Respiratory system compliance (CRS)Phigh 18 cmH2O vs Phigh 34 · CRS significantly higher at Phigh 18 | Phigh 18 cmH2O 43 (IQR 32–50) mL/cmH2O · Phigh 34 20 (IQR 14–24) mL/cmH2O | P < 0.005 |
| Anterior compliance | Phigh 34 10 (IQR 6–11) mL/cmH2O · Phigh 22 cmH2O 18 (IQR 13–25) mL/cmH2O |
Anterior compliance
- Anterior compliance significantly lower at Phigh 34 than at Phigh 22; highest Phigh levels caused significant anterior overdistension
Original publication
Electrical impedance tomography to set high pressure in time-controlled adaptive ventilation. J Crit Care. Published 3 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →