Respiratory failure & ventilation
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 Acute Respiratory Distress Syndrome (ARDS): a phase II randomized controlled trial
- stopped early
Authors' conclusion
The implementation of an individualized PEEP strategy alongside extended lung protection appears viable.
Study context
- Population
- Moderate/severe COVID-19 ARDS with low respiratory system compliance (CRS < 0.6 (mL/Kg)/cmH2O)ITT analysis
- Participants
- 76 participants
- Comparison
- EIT-guided extended lung protection vs ARDSNet low-PEEP strategy
- Interventionn = 37
- Primary endpoint
- Modified lung injury score (mLIS: daily CRS, oxygen requirements, oxygenation, X-rays), hierarchically adjusted for survival and extubation
- Follow-up
- Up to day 28
Methodological detailsphase II, single-centre, Ended prematurely after three consecutive months without enrolment (pandemic subsiding)
- Phase II
- Single-centre
- Ended prematurely after three consecutive months without enrolment (pandemic subsiding)
Primary result
As reported in the abstract
Average mLIS up to 28 days · up to 28 days
- Intervention vs Control: P = 0.95
- Intention-to-treat
- Study ended prematurely
Secondary outcomes
Time to reach 63% of maximum mLIS improvement · faster improvement, driven by oxygenation
P < 0.001
| Outcome | P value |
|---|---|
| X-ray improvementSustained improvement in Intervention | P = 0.001 |
| CRS · up to day 28Sustained increase in Intervention | P = 0.009 |
| Time from randomisation to room-air breathingShorter in Intervention | P = 0.02 |
Survival at 28 days and time to liberation from ventilator
- Not different between groups
Original publication
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS: a phase II randomized controlled trial. Ann Intensive Care. Published 8 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →