Electroencephalographic guided propofol-remifentanil target controlled infusion (TCI) anesthesia with and without dexmedetomidine in a geriatric population: electroencephalographic signatures and clinical evaluation
Authors' conclusion
This pilot study demonstrates that the two proposed anesthetic regimens can be safely used to slowly induce anesthesia and avoid EEG burst suppression patterns.
Study context
- Population
- Patients aged > 69 years scheduled for non-neurologic, non-cardiac surgery with planned intervention time > 60 min, Osorno/Valdivia, Chile
- Participants
- 23 patients
- Comparison
- Propofol vs Dexmedetomidine
- Propofoln = 10reference
- Dexmedetomidinen = 13
Methodological detailspilot, prospective, non-blinded intervention
- Pilot
- Prospective
- Non-blinded intervention
Primary result
As reported in the abstract
Burst suppression and EEG signatures · During slow induction, maintenance, and emergence
- Burst suppression not observed in either group
- EEG signatures differed significantly between groups; propofol group dominated by faster rhythms than dexmedetomidine group
Further findings
| Outcome | P value |
|---|---|
| Time to responsivenessNot significantly different | P = 0.352 |
Postoperative cognitive outcomes (Montreal Cognitive Assessment (MoCa) test, sedation agitation scale) · up to one hour after extubation
- No significant differences between groups
Original publication
Electroencephalographic guided propofol-remifentanil TCI anesthesia with and without dexmedetomidine in a geriatric population: electroencephalographic signatures and clinical evaluation. J Clin Monit Comput. Published 7 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →