Respiratory failure & ventilation
Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials
Authors' conclusion
Plasma IL-18 level provides important additional prognostic information to LCA subphenotypes defined largely by traditional inflammatory biomarkers in two large ARDS cohorts.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients in two multicentre RCTs
- Participants
- 683 vs 511
- Comparison
- High IL-18 vs low IL-18 within the hypoinflammatory LCA class
- SAILSn = 683
- HARP-2n = 511
- Primary endpoint
- Association of IL-18 level with mortality in the hypoinflammatory LCA class
- Follow-up
- 60 days
Methodological detailsSAILS and HARP-2, retrospective, multicentre
- SAILS and HARP-2
- Retrospective
- Multicentre
Primary result
As reported in the abstract
60-d mortality in hypoinflammatory LCA patients with elevated IL-18
Odds ratio (95% CI)P value
SAILS
3.3(1.8–6.1)
P < 0.001HARP-2
2.1(1.2–3.8)
P = 0.009- Hypoinflammatory by LCA but high risk by elevated IL-18, SAILS
- 14%
- Hypoinflammatory by LCA but high risk by elevated IL-18, HARP-2
- 43%
Further findings
Discordance between IL-18 level and LCA class
- Patients discordant by IL-18 level and LCA class (SAILS and HARP-2)
- 33%
Correlation of IL-18 with LCA cytokines
- Only modest correlation
- 0.17-0.47
Original publication
Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials. Crit Care Med. Published 11 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →