Eleven years impact of a stepwise educational program on healthcare associated infections and antibiotics consumption in an intensive care unit of a tertiary hospital in Brazil
Authors' conclusion
A stepwise multifaceted educational program is an effective way to reduce hospital-associated infections, improve the rational use of antibiotics, and reduce costs.
Study context
- Population
- All patients admitted to a 12-bed intensive care unit (ICU) of a tertiary hospital in Brazil, 03/15/2007 to 09/11/20192,406 (79%) survived ICU stay
- Participants
- 3,059 patients
- Exposure
- Stepwise multifaceted educational program, initial vs later period
- Outcome
- Incidence of hospital acquired infections (HAIs) and antibiotic use
Methodological detailsbefore-after study, single-centre, prospective daily collected database
- Before-after study
- Single-centre
- Prospective daily collected database
Main finding
As reported in the abstract
Incidence density of HAIs and antibiotic use, initial vs end of observed period
Catheter related blood infection density, initial → end (events / 1000 patients-day)
4.3 → 0.35
Urinary tract infection density, initial → end (events / 1000 patients-day)
9.2 → 0
Ventilator associated pneumonia density, initial → end (events / 1000 patients-day)
54.9 → 1.5
Days of antibiotic therapy / 1000 patients day, initial → end
797.9 → 292.3
Observational data: associations, not effects.
Further findings
Total cost per patient
- Total cost per patient decreased
Adjusted mortality rate
- Adjusted mortality rate steady during studied period
- 23.2% → 22.9%
Original publication
Eleven years impact of a stepwise educational program on healthcare associated infections and antibiotics consumption in an intensive care unit of a tertiary hospital in Brazil. J Crit Care. Published 19 March 2024. doi:10.
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