Respiratory failure & ventilation
Emulating Target Trials Comparing Early and Delayed Intubation Strategies
Authors' conclusion
When realistic treatment strategies and eligibility criteria are used, strategies that delay intubation result in similar 30-day mortality risks compared with those that intubate early.
Study context
- Population
- Critically ill patients in the Medical Information Mart for Intensive Care-IV database
- Exposure
- Early vs delayed intubation strategies
- Outcome
- 30-day mortality risk
- Follow-up
- 30 days
Methodological detailsobservational cohort study, three target trial emulations, MIMIC-IV database
- Observational cohort study
- Three target trial emulations
- MIMIC-IV database
Main finding
As reported in the abstract
Risk difference, subsequent emulation with more realistic strategies and eligibility criteria (2nd)
0.4 percentage points
95% CI −0.1 to 0.9
Risk difference, subsequent emulation with more realistic strategies and eligibility criteria (3rd)
−0.9 percentage points
95% CI −2.5 to 0.7
Observational data: associations, not effects.
Further findings
Avoidance of intubation with delayed strategy
- Delaying intubation ultimately avoids intubation in most patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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