ICU sedation, delirium & recovery

End-of-life decision disparities according to the gross national income in critically ill patients: a secondary analysis of the ETHICUS-2 study

Ann Intensive CarePublished Secondary analysis of the Ethicus-2 observational study

Authors' conclusion

Outcomes are significantly associated with gross national income (GNI). Moreover, patients in high-income nations tend to have shorter ICU stays before death.

Study context

Population
Adult intensive care units (ICU) patients who died between September 1, 2015, and September 30, 2016
Participants
10,547 ICU non-survivors
Comparison
End-of-life decisions and time to death across gross national income (GNI) groups
Primary endpoint
Association of end-of-life decisions and time to death
Methodological detailspost hoc analysis, prospective recruitment, worldwide, 199 ICUs in 36 countries
  • Post hoc analysis
  • Prospective recruitment
  • Worldwide
  • 199 ICUs in 36 countries

Primary result

As reported in the abstract

Time to death
  • Significantly shorter time to death in high-income vs middle-income countries

Further findings

Therapeutic decisions significantly but variably associated with ICU length of stay (LOS) across GNI groups
No decision in high-income countries: shortest LOS overall
Withdrawing or withholding life-sustaining treatment: longer LOS in middle and high GNI countries

Original publication

End-of-life decision disparities according to the gross national income in critically ill patients: a secondary analysis of the ETHICUS-2 study. Ann Intensive Care. Published 8 March 2025. doi:10.1186/s13613-025-01419-1

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