Endothelial dysfunction in critically ill patients with sepsis and COVID-19 using the albumin transudation rate: A pilot study
Authors' conclusion
ATR was persistently elevated in critically ill patients with sepsis and COVID-19. Sepsis exhibited significantly higher ATR values, suggesting a more pronounced endothelial dysfunction.
Study context
- Population
- Critically ill ICU patients with sepsis or COVID-19, 2022
- Participants
- 36 patients · 3 ICUs
- Exposure
- Sepsis vs COVID-19
- Sepsisn = 18
- COVID-19n = 18reference
- Outcome
- Albumin transudation rate (ATR), measured with a 131I-albumin tracer
- Follow-up
- Days 1, 2, 3, 7, and 10
Methodological detailsmulticentre (3 ICUs)
- Multicentre (3 ICUs)
Main finding
As reported in the abstract
ATR · throughout the ICU stay
- Albumin transudation rate (ATR) significantly higher in sepsis vs COVID-19 throughout the ICU stay, despite lower admission severity scores in sepsis
Observational data: associations, not effects.
Further findings
Clinical assessment of volume status vs measured total blood volume (TBV)
- Clinical assessment frequently misclassified TBV; patients often deemed hypervolemic when objectively hypovolemic, in both conditions
Original publication
Endothelial dysfunction in critically ill patients with sepsis and COVID-19 using the albumin transudation rate: A pilot study. J Crit Care. Published 23 August 2025. doi:10.
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