Enhanced Recovery After Surgery Patients Are Prescribed Fewer Opioids at Discharge: A Propensity-score Matched Analysis
Authors' conclusion
Post-ERAS patients were prescribed significantly fewer opioids at discharge compared to matched pre-ERAS patients.
Study context
- Population
- Patients undergoing hysterectomy (Oct 2016–Nov 2020) or pancreatectomy or hepatectomy (Apr 2017–Nov 2020) at 1 tertiary care center
- Participants
- 3,983 patients
- Exposure
- Post-ERAS vs pre-ERAS patients
- Post-ERASn = 2,054
- Pre-ERASn = 1,929reference
- Outcome
- Discharge opioids (number of pills and oral morphine equivalents)
- Follow-up
- Discharge
Methodological detailspropensity-score matched, single-centre, before-after ERAS implementation
- Propensity-score matched
- Single-centre
- Before-after ERAS implementation
Main finding
As reported in the abstract
Discharge opioid pills and oral morphine equivalents (matched)
| Group | Value | Oral morphine equivalents |
|---|---|---|
| Post-ERAS | 17.4 pills | 129.4 mg |
| Pre-ERAS | 22.0 pills | 167.6 mg |
Value
Post-ERAS17.4 pills
Pre-ERAS22.0 pills
Oral morphine equivalents
Post-ERAS129.4 mg
Pre-ERAS167.6 mg
- Post-ERAS vs Pre-ERAS: P < 0.001 — opioid pills
- Post-ERAS vs Pre-ERAS: P < 0.001 — oral morphine equivalents
Observational data: associations, not effects.
Further findings
Discharge opioids, open surgery (sensitivity analysis) · pills and oral morphine equivalents, each
P < 0.001
Oral morphine equivalents Post-ERAS 138.9 mg · Pre-ERAS 198.7 mg
Discharge opioids, minimally invasive surgery (sensitivity analysis) · pills and oral morphine equivalents, each
P < 0.001
Oral morphine equivalents Post-ERAS 127.1 mg · Pre-ERAS 160.1 mg
Original publication
Enhanced Recovery After Surgery Patients Are Prescribed Fewer Opioids at Discharge: A Propensity-score Matched Analysis. Ann Surg. Published 10 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →