Regional anesthesia

Enhancing anterior shoulder analgesia with a modified PECS II block during shoulder arthroscopy under regional anesthesia alone: a translational anatomical and clinical feasibility study

Reg Anesth Pain MedPublished Translational anatomical and clinical feasibility study

Authors' conclusion

A modified PECS II block performed at the second to third intercostal spaces was associated with improved anterior analgesia and reduced sedation requirements during shoulder arthroscopy under RA alone.

Study context

Population
Adults undergoing arthroscopic shoulder surgery with anterior surgical steps under regional anesthesia (RA) alone
Participants
46 adults
Comparison
Interscalene brachial (ISB)+superficial cervical plexus (SCP)+modified PECS II vs ISB+SCP
Outcome
Intraoperative anterior shoulder pain
Methodological detailscadaveric investigation and retrospective clinical analysis, cadaveric dissection
  • Cadaveric investigation and retrospective clinical analysis
  • Cadaveric dissection

Main finding

As reported in the abstract

P < 0.001

Modified PECS block the only independent predictor of pain reduction
0.0467 (aOR; 95% CI 0.0057 to 0.38)

Secondary outcomes

Complete RA without supplemental sedation

P < 0.001

OutcomeP value
Sedation for painP < 0.001

Cadaveric anatomy

Anterior sensory branches of the intercostobrachial nerve coursing toward the deltopectoral region, occasional anastomoses to the medial pectoral nerve

Original publication

Enhancing anterior shoulder analgesia with a modified PECS II block during shoulder arthroscopy under regional anesthesia alone: a translational anatomical and clinical feasibility study. Reg Anesth Pain Med. Published 11 February 2026. doi:10.1136/rapm-2025-107312

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