Epidemiology and Outcomes Among Adults With Severe Community-Acquired Bacterial Pneumonia Hospitalized in the United States, 2021–2024
Authors' conclusion
The two commonly used sCABP definitions identify a similar population of patients, which is large and resource-intensive. MV practices have evolved since the pandemic, with much less IMV used. Despite these changes, mortality risk from sCABP remains unacceptably high.
Study context
- Population
- Adults hospitalized with severe community-acquired bacterial pneumonia, 849 US acute care hospitals, 2021–2024
- Participants
- 67,439 adults · 849 hospitals
- Exposure
- ICU-defined vs American Thoracic Society (ATS) major criteria-defined severe community-acquired bacterial pneumonia (sCABP)
- Outcome
- Proportion meeting each sCABP definition
Methodological detailsmulticentre, Premier Healthcare Database
- Multicentre
- Premier Healthcare Database
Main finding
As reported in the abstract
- sCABP share of all CABP admissions
- 24.5%
Observational data: associations, not effects.
Further findings
Vasopressors
Mechanical ventilation
Noninvasive positive pressure ventilation
Staphylococcus aureus (patients with known pathogen)
Pseudomonas aeruginosa (patients with known pathogen)
Streptococcus pneumoniae (patients with known pathogen)
Hospital mortality
Readmission · 30 days
- Staphylococcus aureus (patients with known pathogen): known pathogen: n = 851 ICU-sCABP, n = 959 ATS-sCABP
Mechanical ventilation
- Invasive mechanical ventilation (MV) used in under ¼ of patients in either group
Streptococcus pneumoniae (patients with known pathogen)
- Antibiotic classes used were similar
Hospital length of stay (LOS), ICU LOS, MV duration
- Median hospital LOS, 7 d for each group
- 7
- Median ICU LOS, 3 d for each group
- 3
- Median MV duration, 3 d for each group
- 3
Original publication
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