Meningitis in critically ill patients admitted to intensive care unit for severe community-acquired pneumococcal pneumonia
Authors' conclusion
Meningitis was diagnosed in 16% of patients with severe pneumococcal community-acquired pneumonia in whom a lumbar puncture was performed, was more frequent in patients with pneumococcal bacteremia and was associated with more frequent neurological disorders at ICU discharge.
Study context
- Population
- Patients admitted to intensive care unit (ICU) for severe pneumococcal community-acquired pneumonia (American Thoracic Society criteria), January 2006 to December 202088 (34%) had lumbar puncture
- Participants
- 262 patients
- Exposure
- Patients with vs without meningitis
- Meningitisn = 14
- Outcome
- Proportion of patients with meningitis during ICU stay
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Meningitis diagnosed (patients)
14
Proportion among patients with lumbar puncture
16%
Proportion in the whole population
5%
Observational data: associations, not effects.
Further findings
HIV-positive status
P = 0.02
Neurological deficits on ICU admission
P = 0.03
Pneumococcal bacteraemia
P < 0.01
ICU mortality
P = 0.73
Mortality · Day-90
P = 0.83
Neurological disorders at ICU discharge
P < 0.001
Other outcomes at ICU discharge, Day-30 and Day-90
- Did not differ between the two groups
Original publication
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