Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit
An erratum to this article was published (Intensive Care Med, May 2023 ↗)
Authors' conclusion
Eosinophilia ≥ 1 × 109/L is not uncommon in the ICU. According to the timing of eosinophilia, two subsets of patients requiring different etiological workups and management can be distinguished.
Study context
- Population
- Adult intensive care unit (ICU) patients with eosinophilia ≥ 1 × 109/L on two blood samples from the day before admission to the last ICU day, over 6 years0.9% of all ICU hospitalizations
- Participants
- 620 patients
- Exposure
- Early vs delayed eosinophilia
- Outcome
- Prevalence and timing of eosinophilia in ICU
Methodological detailsnational, multicentre (14 centers)
- National
- Multicentre (14 centers)
Main finding
As reported in the abstract
- Eosinophilia ≥ 1 × 109/L among all ICU hospitalizations
- 0.9%
Observational data: associations, not effects.
Further findings
Survival · Day 60 after ICU admission
P = 0.219
Etiology and presentation, ICU-Eo1
- Respiratory conditions
- 14.9%
- Hematological conditions
- 25.8%
- Symptomatic (mainly respiratory and cardiovascular)
- 58.1%
- Systemic corticosteroids required
- 32.2%
Etiology and presentation, ICU-Eo2
- Eosinophil-related organ involvement
- 25%
- Drug-induced eosinophilia
- 46.8%
Risk factors for death at D60 (multivariate analysis) · Day 60
- ICU-Eo1: current immunosuppressant therapy at ICU admission, onco-hematological origin, vasopressors at ICU admission
- ICU-Eo2: older age, vasopressors or mechanical ventilation at onset of eosinophilia
Original publication
Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit. Intensive Care Med. Published 1 February 2023. doi:10.
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