Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review and meta-analysis
Authors' conclusion
This systematic review reporting the FAPP evaluation revealed a high accuracy.
Study context
- Population
- Respiratory samples tested for the 15 typical bacteria of the panel; studies from PubMed and EMBASE, 2010–2022
- Participants
- 8,968 participants · 30 studies
- Comparison
- FilmArray® Pneumonia Plus Panel vs bacterial culture
- Outcome
- Overall diagnostic accuracy (sensitivity and specificity)
Methodological details21 of 30 studies related to intensive care
- 21 of 30 studies related to intensive care
Pooled result
As reported in the abstract
Overall diagnostic accuracy of FAPP vs bacterial culture
Overall sensitivity
94%
95% CI 91–95
Overall specificity
98%
95% CI 97–98
Further pooled results
Log diagnostic OR
- Log diagnostic OR
- 6.35 (95% CI 6.05-6.65)
Out-of-panel bacteria
- Bacteria detected in culture not included in the FAPP panel
- 9.3% (95% CI 9.2-9.5)
Original publication
Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review and meta-analysis. Anaesth Crit Care Pain Med. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →