Epidemiology of continuous renal replacement therapy in critically ill adults on extracorporeal membrane oxygenation (ECMO): A multicenter cohort study
Authors' conclusion
In this multicenter ECMO-cohort, CRRT was independently associated with higher in-hospital mortality regardless of ECMO configuration and the timing of CRRT initiation.
Study context
- Population
- Adults receiving ECMO, 2009–2023512 (37.7%) received continuous renal replacement therapy (CRRT)
- Participants
- 1,358 adults
- Exposure
- CRRT before, early or late relative to ECMO cannulation vs ECMO-only
- CRRT-beforen = 82
- CRRT-earlyn = 234
- CRRT-laten = 196
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, multivariable logistic regression
- Multicentre
- Multivariable logistic regression
Main finding
As reported in the abstract
Each group vs ECMO-onlyAdjusted odds ratio (95% CI)
CRRT-before
4.95(2.62–9.35)
CRRT-early
3.10(2.14–4.50)
CRRT-late
4.08(2.82–5.89)
Observational data: associations, not effects.
Further findings
RRT dependence at discharge among ECMO survivors with CRRT
Predictors of mortality
- Older age, sepsis and VA-ECMO were independent predictors of mortality
Original publication
Epidemiology of continuous renal replacement therapy in critically ill adults on ECMO: A multicenter cohort study. J Crit Care. Published 13 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →