Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRT Network (CRRTnet) Registries
Authors' conclusion
Critically ill cirrhosis/ACLF patients initiated on CRRT in the absence of liver transplantation had high in-hospital mortality.
Study context
- Population
- Critically ill patients with cirrhosis/ACLF receiving continuous renal replacement therapy (CRRT) in the ICU, academic tertiary care hospitals in the US and Canada
- Participants
- 245 vs 206
- Exposure
- HARMONY vs CRRTnet
- HARMONYn = 245
- CRRTnetn = 206
- Outcome
- In-hospital mortality
Methodological detailsparallel analysis of two registries, multicentre
- Parallel analysis of two registries
- Multicentre
Main finding
As reported in the abstract
Survival to hospital discharge
Observational data: associations, not effects.
Further findings
In-hospital mortality by chronic liver failure-C ACLF score, HARMONY (multivariable)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher chronic liver failure-C ACLF scores | 1.03 (1.01–1.05) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- In-hospital mortality by chronic liver failure-C ACLF score, HARMONY (multivariable): independently associated with increased in-hospital mortality
Original publication
Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRTnet Registries. Crit Care Med. Published 17 September 2026. doi:10.
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