Paediatric anaesthesia & critical care
Epidemiology, ventilation management, and clinical outcomes in children (PRoVENT-PED): first results from the 10-year, investigator-initiated, international, multicentre, prospective cohort study
Authors' conclusion
Ventilation management in children varies substantially by age and PARDS status. Among potentially modifiable ventilation factors, only PEEP, ΔP, and FiO2 were associated with 28-day mortality.
Study context
- Population
- Invasively ventilated (≥12 h) critically ill children younger than 18 years in 83 intensive care unit (ICUs) across 34 countries; preterm infants <40 weeks postconceptional age and ECMO excluded
- Participants
- 1,427 participants · 83 ICUs · 34 countries
- Exposure
- Paediatric acute respiratory distress syndrome (PARDS) vs no PARDS; predefined age groups
- PARDSn = 164
- No PARDSn = 1,263reference
- Outcome
- 28-day ICU mortality
- Follow-up
- 28 days
Methodological detailsinvestigator-initiated, international, multicentre, observational, registry, Enrolled April 1 to June 30, 2024, and Oct 1 to Dec 31, 2024
- Investigator-initiated
- International
- Multicentre
- Observational
- Registry
- Enrolled April 1 to June 30, 2024, and Oct 1 to Dec 31, 2024
Main finding
As reported in the abstract
- 28-day ICU mortality, all children (201 of 1427)
- 14%
- 28-day ICU mortality lowest in neonates (3 of 112)
- 3%
Observational data: associations, not effects.
Further findings
PARDS incidence
- PARDS identified in 164 of 1427 children; most frequent in preschool-aged children (3 to <6 years)
- 11%
Ventilation management
- Ventilator management varied by age and PARDS status; decreased age and PARDS associated with exposure to high airway pressures
Modifiable factors associated with ICU mortality
- Positive end-expiratory pressure (PEEP), driving pressure (ΔP) and FiO2 independently associated with ICU mortality
Original publication
Epidemiology, ventilation management, and clinical outcomes in children (PRoVENT-PED): first results from the 10-year, investigator-initiated, international, multicentre, prospective cohort study. Lancet Respir Med. Published 1 May 2026. doi:10.
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