Pediatric anesthesia & critical care
Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock
Authors' conclusion
In this study, those receiving epinephrine had greater 30-day mortality but no difference in MAKE30.
Study context
- Population
- Patients aged 1 month to 18 years presenting to the ED with septic shock without known cardiac dysfunction, starting epinephrine or norepinephrine infusion within 24 hours of ED arrival, freestanding quaternary care children's hospital, 2017–2023
- Participants
- 231 encounters
- Exposure
- Epinephrine vs norepinephrine as first vasoactive medication
- Epinephrinen = 147
- Norepinephrinen = 84reference
- Outcome
- Major adverse kidney events (MAKE30)
- Follow-up
- 30 days
Methodological detailssingle-centre, propensity score matching, inverse probability of treatment weighting
- Single-centre
- Propensity score matching
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
MAKE30
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Epinephrine | Norepinephrine | Risk difference (95% CI) | |
|---|---|---|---|---|
| 30-day mortality (2:1 propensity matched) | 3.7% | 0% | 3.7% (0.2%–7.2%) | |
| −50510Difference (linear scale) |
| Outcome | Epinephrine | Norepinephrine |
|---|---|---|
| 30-day mortality · unadjusted | 4.1% | 0 events |
- 30-day mortality (2:1 propensity matched): 2:1 propensity matching
Original publication
Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock. JAMA Netw Open. Published 1 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →