Perioperative medicine & outcomes

Estimating the effect of frailty on longer‐term survival following emergency laparotomy: an observational study using National Emergency Laparotomy Audit data*

AnaesthesiaPublished Retrospective cohort study

Authors' conclusion

For older people living with frailty, increased risk of death persists further than the immediate postoperative period.

Study context

Population
Patients undergoing emergency laparotomy, National Emergency Laparotomy Audit (UK)
Exposure
Clinical Frailty Scale (CFS) 4–9 vs CFS 1-3
Outcome
Short- (≤ 90 days) and longer-term (> 90 days) mortality
Methodological detailsprospectively collected national audit data, linked mortality data
  • Prospectively collected national audit data
  • Linked mortality data

Main finding

As reported in the abstract

Death from 90 days post-surgery · > 90 days
Each group vs CFS 1-3AHR for death (95% CI)
CFS 4
1.52(1.41–1.64)
CFS 5
1.69(1.57–1.82)
CFS 6
2.14(1.98–2.31)
CFS 7
2.97(2.59–3.41)
CFS 8
4.24(3.19–5.64)
CFS 9
3.34(2.17–5.14)

Observational data: associations, not effects.

Further findings

Death in the first 90 days after surgery

Frailty strongly associated with hazard of death

Original publication

Estimating the effect of frailty on longer‐term survival following emergency laparotomy: an observational study using National Emergency Laparotomy Audit data*. Anaesthesia. Published 27 May 2025. doi:10.1111/anae.16644

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