Pediatric anesthesia & critical care
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Authors' conclusion
Airway occlusion maneuvers may be appropriate alternatives to esophageal pressure measurement to estimate the inspiratory effort in children, and Pocc represents the most promising target.
Study context
- Population
- Children 1 month to 18 years with ARDS enrolled in an ongoing RCT of a lung and diaphragm protective ventilation strategy653 inspiratory, 713 expiratory holds
- Participants
- 97 children
- Comparison
- Airway occlusion pressures vs esophageal pressure swing
- Primary endpoint
- Correlation between ∆Pes during tidal breathing and airway pressure during three occlusion maneuvers
Methodological detailsphysiologic data, repeated measure correlations, linear regression
- Physiologic data
- Repeated measure correlations
- Linear regression
Primary result
As reported in the abstract
Correlation with ∆Pes
Pocc
0.68
r
PMI
0.60
r
P0.1
0.42
r
Further findings
Estimation of ∆Pes from Pocc (regression)
- ∆Pes = 0.66 × Pocc; R2
- 0.82
- Pocc cut-points: high specificity and moderate sensitivity to detect ∆Pes thresholds for high and low effort
Relationship by age (infant, child, adolescent) or mode (SIMV vs Pressure Support) (subgroup)
- Minimal differences for Pocc vs ∆Pes; more apparent with P0.1 and PMI
Original publication
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy. Crit Care. Published 29 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →