Pediatric anesthesia & critical care
Inverse ratio ventilation versus conventional ratio ventilation during one lung ventilation in neonatal open repair of esophageal atresia/tracheoesophageal fistula: A randomized clinical trial
Primary result · Severe desaturations (requiring stopping of surgery)Result — go to the resultRelative risk 0.429 95% CI 0.129–1.426Authors' conclusion
There may be a role for inverse ratio ventilation with appropriate positive end-expiratory pressure to reduce the incidence of hypoxemia during open repair of esophageal atresia/tracheoesophageal fistula in neonates
Study context
- Population
- Term neonates undergoing open right thoracotomy for esophageal atresia/tracheoesophageal fistula repair
- Participants
- 40 neonates
- Comparison
- Inverse ratio ventilation vs conventional ratio ventilation during OLV
- Primary endpoint
- Incidence of desaturation episodes requiring stopping the procedure and lung reinflation
Primary result
As reported in the abstract
Severe desaturations (requiring stopping of surgery)
Relative risk
0.429
95% CI 0.129–1.426
By group
IRV vs CRV
RR 0.429 (95% CI 0.129–1.426)
Secondary outcomes
| Outcome | IRV | CRV | RR (95% CI) | |
|---|---|---|---|---|
| All desaturations (including those requiring only increased ventilatory support or inspired oxygen) | 40% | 75% | 0.533 (0.295–0.965) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Mean difference (95% CI) | |
|---|---|---|
| Length of surgical procedureSignificantly shorter with inverse ratio ventilation | −16.3 (−31.64 to −0.958) | |
| −40−20020Difference (linear scale) |
Hemodynamic stability
- No significant difference in hemodynamic stability between groups
Safety
- No significant difference in complications apart from higher blood loss in IRV
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Inverse ratio ventilation versus conventional ratio ventilation during one lung ventilation in neonatal open repair of esophageal atresia/tracheoesophageal fistula: A randomized clinical trial. Paediatr Anaesth. Published 8 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →