Paediatric anaesthesia & critical care
Diaphragm Thickening Fraction for Predicting Esophageal Pressure and Ventilator Weaning in Children
Authors' conclusion
Our research shows that DTF should be used with caution in children because it does not seem to have a strong correlation with measures of respiratory effort and does not reliably predict SBT or extubation outcomes.
Study context
- Population
- Mechanically ventilated children with ARDS
- Participants
- 60 / 88 / 171
- Comparison
- Diaphragm thickening fraction (DTF) vs ΔPes and SBT/extubation outcomes
- Early failuren = 60
- Late failuren = 88
- Successn = 171
- Primary endpoint
- Correlation of daily DTF with ΔPes and prediction of SBT and extubation outcomes
Primary result
As reported in the abstract
SBT DTF by SBT outcome (median)
P = 0.69
- Correlation between daily DTF and ΔPes
- r = 0.10 (95% CI, 0.01-0.19)
Further findings
| Outcome | Successfully extubated | Reintubated | Prolonged NIV | P value |
|---|---|---|---|---|
| SBT DTF predicting extubation success vs failure (reintubation or prolonged NIV)Across the three groups · not predictive | median 19% (IQR 11%–31%) · n = 124 | median 23% (IQR 16%–30%) · n = 12 | median 17% (IQR 10%–23%) · n = 30 | P = 0.3 |
- SBT DTF predicting extubation success vs failure (reintubation or prolonged noninvasive ventilation (NIV)) — AUC for extubation outcome
- 0.54 [95% CI, 0.44-0.64]
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diaphragm Thickening Fraction for Predicting Esophageal Pressure and Ventilator Weaning in Children. Chest. Published 23 March 2026. doi:10.
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