Pediatric anesthesia & critical care
Ventilator Weaning and Terminal Extubation: Withdrawal of Life-Sustaining Therapy in Children. Secondary Analysis of the Death One Hour After Terminal Extubation Study
Authors' conclusion
Decreasing ventilatory support before WLST with extubation in children does occur. This practice was not associated with significant differences in palliative analgosedation doses or time to death after extubation.
Study context
- Population
- Patients 0–21 years old who died after withdrawal of life-sustaining therapies, 10 US PICUs, 2009–2021
- Participants
- 913 patients · 10 PICUs
- Comparison
- Decrease in ventilatory support before WLST vs terminal extubation (TE) without prior decrease
- TE without decreasen = 652reference
- Clinically relevant decreasen = 100
- Likely incidental decreasen = 161
Methodological detailspreplanned secondary analysis
- Preplanned secondary analysis
Primary result
As reported in the abstract
Ventilatory support before WLST · 6 hours prior to extubation
Further findings
Patient characteristics (weight, BMI, unit type, primary diagnostic category, coma, time to death after WLST, analgosedative requirements, postextubation respiratory support modality)
- No significant differences between groups
Original publication
Ventilator Weaning and Terminal Extubation: Withdrawal of Life-Sustaining Therapy in Children. Secondary Analysis of the Death One Hour After Terminal Extubation Study. Crit Care Med. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →